Commercial Real Estate in Santa Fe, New Mexico

Browse 208 commercial real estate in Santa Fe, New Mexico (NM) with an average asking rent of $22 per SF, an average asking sale price of $338 per SF, and an average size of 7,968 SF.

Current Inventory208
Average Available Size7,968 SF
Total Available Size1.4M SF
Average Asking Price—
901 W San Mateo Rd Unit G listing image
Lease Other

901 W San Mateo Rd Unit G

901 W San Mateo Rd Unit G, Santa Fe, NM 87505

  • $26.9 SF/year
  • 800 SF
  • 800 SF building
  • 2 ac

Discover a versatile 800-square-foot live/work space in the heart of Ironestone Gardens. This open-concept unit features concrete flooring, a loft area, and a kitchen equipped with a gas stove, fridge, and sink. The bathroom includes a shower, and a gas heater ensures year-round comfort. Enjoy the convenience of off-street parking and a prime central location near Midtown Bistro and Iconik Coffee Roasters. Ideal for creatives or professionals seeking a functional and stylish space, this unique unit offers the perfect blend of work and living in a vibrant community.

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5 Calle Medico - Medical/Office Space Available listing image
Lease HealthcareOffice

5 Calle Medico - Medical/Office Space Available

5 Cll Medico, Santa Fe, NM 87505

  • $23 SF/year
  • 1,530 SF
  • 10,040 SF building
  • 1 ac

Excellent opportunity to lease healthcare or medical office space at 5 Calle Medico in Santa Fe, ideally located immediately adjacent to CHRISTUS St. Vincent Regional Medical Center and within one of Santa Fe’s established medical office corridors.The property features an attractive Southwestern/Pueblo-style architectural design, with the distinctive stucco exterior and clean regional character commonly associated with Santa Fe. The professional setting is further enhanced by a tenant mix consisting primarily of medical and healthcare-related professionals, creating a natural environment for practices seeking proximity to complementary providers.The available suite is located on the second level of the building and is conveniently serviced by an elevator, providing easy access for patients, staff, and visitors.The space offers a functional layout well suited for a variety of healthcare, clinical, therapy, or professional medical uses. The existing floor plan includes multiple private treatment/exam rooms, a large central hall/reception or work area, restroom facilities, a kitchen area, laundry area, and additional flexible-use space.Its location provides convenient access for patients and staff and places the property in close proximity to the hospital, physicians, specialists, and other healthcare providers.Property Highlights:Premier Calle Medico medical-office locationImmediately adjacent to CHRISTUS St. Vincent Regional Medical CenterAttractive Southwestern/Pueblo-style architectureProfessional medical and healthcare-oriented tenant mixSecond-floor suite with elevator accessMultiple private exam, treatment, or consultation roomsLarge central area suitable for reception, administrative, or clinical useExisting kitchen and laundry areasMultiple restroom facilitiesFlexible floor plan adaptable to a variety of healthcare and medical usersConvenient access for patients, employees, and referring providersAn excellent opportunity for a medical practice, behavioral health provider, therapy practice, specialty clinic, or other healthcare-related user seeking space in an established professional medical environment in one of Santa Fe’s most desirable healthcare locations.

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1 Plaza La Prensa listing image
Sale/Lease Office

1 Plaza La Prensa

1 Plaza La Prensa, Santa Fe, NM 87507

  • $22 SF/year
  • 46,975 SF
  • 46,975 SF building
  • 6 ac

1 Plaza La Prensa Road showcases modern architecture and functional design. This 46,975 square-foot office flex building on 5.84 acres was built in 2004 and houses the State of New Mexico Human Services.Initially built with one-third office space and two-thirds light manufacturing and warehousing, it was renovated in 2019 to be entirely office space. However, it can revert to a mixed-use office and warehouse setup. The versatile building includes a dock and a drive-in door, attracting various tenants. The property also offers parking spaces. 1 Plaza La Prensa Road is ideally located a few hundred feet from the Interstate 25 on-ramp and off-ramp, offering easy access to Santa Fe and the entire state. The nearby Santa Fe Bypass Road further enhances connectivity to northwestern New Mexico. Santa Fe, in north-central New Mexico, is connected by Interstate 25 to Albuquerque (55 miles south) and Denver (380 miles north).

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Downtown Santa Fe Mixed Use Duplex listing image
Sale MultifamilyOffice

Downtown Santa Fe Mixed Use Duplex

417 Orchard Dr, 419 Orchard, Santa Fe, NM 87501

  • $1.5M
  • 2,444 SF building
  • 0 ac

Real Estate Advisors, LLC is pleased to offer for sale 417, 417½ and 419 Orchard Drive, two adobe buildings on ±14,531 square feet of land in downtown Santa Fe. The two lots share one tax parcel and a large graveled parking area with access from both Orchard Drive and Paseo de Peralta.Both buildings date to 1950. 417 and 417½ is a duplex, both units are 1 bed 1 bath. 419 is a single familyresidence with an attached garage. Each propertyhas a full kitchen and full bath. One unit in 417is currently used as anoffice.BCD zoning allows a broad range of office and commercial uses, subject to city review. The offering will appeal to short term rental ownership, businesses who want a downtown address with its own parking, and to an investor looking for a cash flowing asset.

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No image available
Lease Retail

Sabino Shopping Center

604 N Guadalupe St Ste C, Santa Fe, NM 87501

  • $30 SF/year
  • 1,250 SF

Available for lease, Suite C is a move-in-ready ±1,250 RSF retail space within the ±5,000 SF Sabino Shopping Center at 604 N Guadalupe St in Santa Fe. The center is directly adjacent to Market Street grocery within the established DeVargas Mall shopping complex. The suite features a second-generation retail buildout, shared on-site parking, prominent visibility, and access to ongoing retail foot traffic. Lease rate is $30.00/SF per year.An existing security system is in use; functionality is not guaranteed by the owner. The suite is suitable for boutique retail, wellness, personal services, specialty retail, and other customer-facing uses. Zoning is SC2, Planned Shopping Center District Community.

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1907 St. Michael’s Drive Suite H listing image
Lease Office

1907 St. Michael’s Drive Suite H

1907 St Michaels Dr H, Santa Fe, NM 87505

  • $48 SF/year
  • 300 SF

Attractive ±300 SF second-floor professional office suite conveniently located along St. Michael's Drive in central Santa Fe. Suite H features a spacious, versatile layout, private full bathroom, balcony, and beautiful plantation shutters that provide abundant natural light. The inviting space can comfortably accommodate two to three desks, a client seating area, or a small conference table.The property offers convenient access to surrounding businesses, shopping, professional services, and major Santa Fe thoroughfares. Its central location, private amenities, and flexible workspace make Suite H an excellent opportunity for consulting, administrative services, or other professional office users seeking a comfortable and functional business environment.$1,200/Month | Tenant Pays Utilities | Stair Access Only (No Elevator)Prime St. Michael's DrivePrivate Full BathroomPrivate BalconySpacious, Flexible Office Layout Prime St. Michael's DrivePrivate Full BathroomPrivate BalconySpacious, Flexible Office Layout

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