Commercial Real Estate for Lease in Santa Fe, New Mexico

Browse 100 commercial spaces for lease in Santa Fe, New Mexico (NM) with an average asking rent of $22 per SF and an average size of 7,968 SF.

Current Inventory100
Average Available Size7,968 SF
Total Available Size1.4M SF
Average Asking Rent$22/SF/YR
901 W San Mateo Rd Unit G listing image
Lease Other

901 W San Mateo Rd Unit G

901 W San Mateo Rd Unit G, Santa Fe, NM 87505

  • $26.9 SF/year
  • 800 SF
  • 800 SF building
  • 2 ac

Discover a versatile 800-square-foot live/work space in the heart of Ironestone Gardens. This open-concept unit features concrete flooring, a loft area, and a kitchen equipped with a gas stove, fridge, and sink. The bathroom includes a shower, and a gas heater ensures year-round comfort. Enjoy the convenience of off-street parking and a prime central location near Midtown Bistro and Iconik Coffee Roasters. Ideal for creatives or professionals seeking a functional and stylish space, this unique unit offers the perfect blend of work and living in a vibrant community.

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5 Calle Medico - Medical/Office Space Available listing image
Lease HealthcareOffice

5 Calle Medico - Medical/Office Space Available

5 Cll Medico, Santa Fe, NM 87505

  • $23 SF/year
  • 1,530 SF
  • 10,040 SF building
  • 1 ac

Excellent opportunity to lease healthcare or medical office space at 5 Calle Medico in Santa Fe, ideally located immediately adjacent to CHRISTUS St. Vincent Regional Medical Center and within one of Santa Fe’s established medical office corridors.The property features an attractive Southwestern/Pueblo-style architectural design, with the distinctive stucco exterior and clean regional character commonly associated with Santa Fe. The professional setting is further enhanced by a tenant mix consisting primarily of medical and healthcare-related professionals, creating a natural environment for practices seeking proximity to complementary providers.The available suite is located on the second level of the building and is conveniently serviced by an elevator, providing easy access for patients, staff, and visitors.The space offers a functional layout well suited for a variety of healthcare, clinical, therapy, or professional medical uses. The existing floor plan includes multiple private treatment/exam rooms, a large central hall/reception or work area, restroom facilities, a kitchen area, laundry area, and additional flexible-use space.Its location provides convenient access for patients and staff and places the property in close proximity to the hospital, physicians, specialists, and other healthcare providers.Property Highlights:Premier Calle Medico medical-office locationImmediately adjacent to CHRISTUS St. Vincent Regional Medical CenterAttractive Southwestern/Pueblo-style architectureProfessional medical and healthcare-oriented tenant mixSecond-floor suite with elevator accessMultiple private exam, treatment, or consultation roomsLarge central area suitable for reception, administrative, or clinical useExisting kitchen and laundry areasMultiple restroom facilitiesFlexible floor plan adaptable to a variety of healthcare and medical usersConvenient access for patients, employees, and referring providersAn excellent opportunity for a medical practice, behavioral health provider, therapy practice, specialty clinic, or other healthcare-related user seeking space in an established professional medical environment in one of Santa Fe’s most desirable healthcare locations.

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1 Plaza La Prensa listing image
Sale/Lease Office

1 Plaza La Prensa

1 Plaza La Prensa, Santa Fe, NM 87507

  • $22 SF/year
  • 46,975 SF
  • 46,975 SF building
  • 6 ac

1 Plaza La Prensa Road showcases modern architecture and functional design. This 46,975 square-foot office flex building on 5.84 acres was built in 2004 and houses the State of New Mexico Human Services.Initially built with one-third office space and two-thirds light manufacturing and warehousing, it was renovated in 2019 to be entirely office space. However, it can revert to a mixed-use office and warehouse setup. The versatile building includes a dock and a drive-in door, attracting various tenants. The property also offers parking spaces. 1 Plaza La Prensa Road is ideally located a few hundred feet from the Interstate 25 on-ramp and off-ramp, offering easy access to Santa Fe and the entire state. The nearby Santa Fe Bypass Road further enhances connectivity to northwestern New Mexico. Santa Fe, in north-central New Mexico, is connected by Interstate 25 to Albuquerque (55 miles south) and Denver (380 miles north).

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Lease Retail

Sabino Shopping Center

604 N Guadalupe St Ste C, Santa Fe, NM 87501

  • $30 SF/year
  • 1,250 SF

Available for lease, Suite C is a move-in-ready ±1,250 RSF retail space within the ±5,000 SF Sabino Shopping Center at 604 N Guadalupe St in Santa Fe. The center is directly adjacent to Market Street grocery within the established DeVargas Mall shopping complex. The suite features a second-generation retail buildout, shared on-site parking, prominent visibility, and access to ongoing retail foot traffic. Lease rate is $30.00/SF per year.An existing security system is in use; functionality is not guaranteed by the owner. The suite is suitable for boutique retail, wellness, personal services, specialty retail, and other customer-facing uses. Zoning is SC2, Planned Shopping Center District Community.

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1907 St. Michael’s Drive Suite H listing image
Lease Office

1907 St. Michael’s Drive Suite H

1907 St Michaels Dr H, Santa Fe, NM 87505

  • $48 SF/year
  • 300 SF

Attractive ±300 SF second-floor professional office suite conveniently located along St. Michael's Drive in central Santa Fe. Suite H features a spacious, versatile layout, private full bathroom, balcony, and beautiful plantation shutters that provide abundant natural light. The inviting space can comfortably accommodate two to three desks, a client seating area, or a small conference table.The property offers convenient access to surrounding businesses, shopping, professional services, and major Santa Fe thoroughfares. Its central location, private amenities, and flexible workspace make Suite H an excellent opportunity for consulting, administrative services, or other professional office users seeking a comfortable and functional business environment.$1,200/Month | Tenant Pays Utilities | Stair Access Only (No Elevator)Prime St. Michael's DrivePrivate Full BathroomPrivate BalconySpacious, Flexible Office Layout Prime St. Michael's DrivePrivate Full BathroomPrivate BalconySpacious, Flexible Office Layout

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3060 Cerrillos Rd listing image
Sale/Lease RetailIndustrial

3060 Cerrillos Rd

3060 Cerrillos Rd, Santa Fe, NM 87507

  • $2M
  • $14 SF/year
  • 12,200 SF
  • 12,200 SF building
  • 1 ac

FREESTANDING CERRILLOS ROAD RETAIL/FLEX BUILDING — FOR SALE OR LEASE3060 Cerrillos Road is a 12,200-square-foot freestanding commercial building offering excellent visibility, approximately 75 surface parking spaces, flexible retail and warehouse space, two loading docks, one drive-in door and 16-foot clear height along one of Santa Fe’s most established commercial corridors.The property benefits from approximately 1.26 acres of combined functional site area, comprising the fee-owned parcel together with recorded easement areas providing additional parking, ingress, egress and loading-dock access. The property has direct ingress from Cerrillos Road and access through Cielo Court.Goodwill Industries of New Mexico has successfully occupied the property for approximately 25 years. The current lease expires March 31, 2027. A purchaser may acquire the property before lease expiration and receive the remaining rental income, followed by owner occupancy, re-leasing or repositioning beginning April 1, 2027.PROPERTY HIGHLIGHTS12,200-square-foot freestanding retail/flex buildingOffered for sale at $2,395,000Available for lease at $13.95/SF NNNEstimated NNN expenses of $3.00/SFGoodwill rental income through March 31, 2027Anticipated occupancy beginning April 1, 2027Approximately 25 years of successful Goodwill occupancyApproximately 1.26 acres of combined functional site area, including recorded easement areasExclusive recorded parking and loading-dock easementNonexclusive access over Cielo CourtTwo loading docks plus one drive-in doorApproximately 75 surface parking spaces16-foot clear heightC-2 General Commercial zoningBuilding and monument signageApproximately 39,638 vehicles per dayProminent Cerrillos Road visibility and accessOffered for sale or leaseDo not disturb tenant FREESTANDING CERRILLOS ROAD RETAIL/FLEX BUILDING — FOR SALE OR LEASE3060 Cerrillos Road is a 12,200-square-foot freestanding commercial building offering excellent visibility, approximately 75 parking spaces, flexible retail and warehouse space, two loading docks, one drive-in door and 16-foot clear height along one of Santa Fe’s most established commercial corridors.The property benefits from approximately 1.26 acres of combined functional site area, comprising the fee-owned parcel together with recorded easement areas providing additional parking, ingress, egress and loading-dock access. The property has direct ingress from Cerrillos Road and access through Cielo Court.Goodwill Industries of New Mexico has successfully occupied the property for approximately 25 years. The current lease expires March 31, 2027, providing rental income through the lease term and anticipated occupancy for a new tenant or owner-user beginning April 1, 2027.PROPERTY HIGHLIGHTS12,200-square-foot freestanding buildingOffered for sale at $2,395,000 or available for leaseGoodwill rental income through March 31, 2027Anticipated occupancy beginning April 1, 2027Approximately 25 years of successful Goodwill occupancyApproximately 1.26 acres of combined functional site area, including recorded easement areasExclusive recorded parking, access and loading-dock easementTwo loading docks plus one drive-in doorApproximately 75 surface parking spaces16-foot clear heightC-2 General Commercial zoningProminent Cerrillos Road visibilityApproximately 39,638 vehicles per dayBuilding and monument signageDo not disturb tenant

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