Office Commercial Real Estate for Lease in Santa Fe, New Mexico

Browse 44 office spaces for lease in Santa Fe, New Mexico (NM) with an average asking rent of $23 per SF and an average size of 3,877 SF.

Current Inventory44
Average Available Size3,877 SF
Total Available Size310.2K SF
Average Asking Rent$23/SF/YR
5 Calle Medico - Medical/Office Space Available listing image
Lease HealthcareOffice

5 Calle Medico - Medical/Office Space Available

5 Cll Medico, Santa Fe, NM 87505

  • $23 SF/year
  • 1,530 SF
  • 10,040 SF building
  • 1 ac

Excellent opportunity to lease healthcare or medical office space at 5 Calle Medico in Santa Fe, ideally located immediately adjacent to CHRISTUS St. Vincent Regional Medical Center and within one of Santa Fe’s established medical office corridors.The property features an attractive Southwestern/Pueblo-style architectural design, with the distinctive stucco exterior and clean regional character commonly associated with Santa Fe. The professional setting is further enhanced by a tenant mix consisting primarily of medical and healthcare-related professionals, creating a natural environment for practices seeking proximity to complementary providers.The available suite is located on the second level of the building and is conveniently serviced by an elevator, providing easy access for patients, staff, and visitors.The space offers a functional layout well suited for a variety of healthcare, clinical, therapy, or professional medical uses. The existing floor plan includes multiple private treatment/exam rooms, a large central hall/reception or work area, restroom facilities, a kitchen area, laundry area, and additional flexible-use space.Its location provides convenient access for patients and staff and places the property in close proximity to the hospital, physicians, specialists, and other healthcare providers.Property Highlights:Premier Calle Medico medical-office locationImmediately adjacent to CHRISTUS St. Vincent Regional Medical CenterAttractive Southwestern/Pueblo-style architectureProfessional medical and healthcare-oriented tenant mixSecond-floor suite with elevator accessMultiple private exam, treatment, or consultation roomsLarge central area suitable for reception, administrative, or clinical useExisting kitchen and laundry areasMultiple restroom facilitiesFlexible floor plan adaptable to a variety of healthcare and medical usersConvenient access for patients, employees, and referring providersAn excellent opportunity for a medical practice, behavioral health provider, therapy practice, specialty clinic, or other healthcare-related user seeking space in an established professional medical environment in one of Santa Fe’s most desirable healthcare locations.

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1 Plaza La Prensa listing image
Sale/Lease Office

1 Plaza La Prensa

1 Plaza La Prensa, Santa Fe, NM 87507

  • $22 SF/year
  • 46,975 SF
  • 46,975 SF building
  • 6 ac

1 Plaza La Prensa Road showcases modern architecture and functional design. This 46,975 square-foot office flex building on 5.84 acres was built in 2004 and houses the State of New Mexico Human Services.Initially built with one-third office space and two-thirds light manufacturing and warehousing, it was renovated in 2019 to be entirely office space. However, it can revert to a mixed-use office and warehouse setup. The versatile building includes a dock and a drive-in door, attracting various tenants. The property also offers parking spaces. 1 Plaza La Prensa Road is ideally located a few hundred feet from the Interstate 25 on-ramp and off-ramp, offering easy access to Santa Fe and the entire state. The nearby Santa Fe Bypass Road further enhances connectivity to northwestern New Mexico. Santa Fe, in north-central New Mexico, is connected by Interstate 25 to Albuquerque (55 miles south) and Denver (380 miles north).

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1907 St. Michael’s Drive Suite H listing image
Lease Office

1907 St. Michael’s Drive Suite H

1907 St Michaels Dr H, Santa Fe, NM 87505

  • $48 SF/year
  • 300 SF

Attractive ±300 SF second-floor professional office suite conveniently located along St. Michael's Drive in central Santa Fe. Suite H features a spacious, versatile layout, private full bathroom, balcony, and beautiful plantation shutters that provide abundant natural light. The inviting space can comfortably accommodate two to three desks, a client seating area, or a small conference table.The property offers convenient access to surrounding businesses, shopping, professional services, and major Santa Fe thoroughfares. Its central location, private amenities, and flexible workspace make Suite H an excellent opportunity for consulting, administrative services, or other professional office users seeking a comfortable and functional business environment.$1,200/Month | Tenant Pays Utilities | Stair Access Only (No Elevator)Prime St. Michael's DrivePrivate Full BathroomPrivate BalconySpacious, Flexible Office Layout Prime St. Michael's DrivePrivate Full BathroomPrivate BalconySpacious, Flexible Office Layout

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1701 Calle Medico listing image
Lease Office

1701 Calle Medico

1701 Old Pecos Trail, Santa Fe, NM 87505

  • Negotiable
  • 2,055 – 18,443 SF
  • 18,433 SF building
  • 4 Spaces

Suites may be combined for full-floor or multi-floor users. Usable SF is the area inside each suite's wall.Locally Owned & Professionally managedConveniently located minutes away from I-25, Santa Fe Plaza, various amenities, and the Medical CorridorNatural Lighting available in most suitesCommunity of local and national office tenantsIn close proximity to prominent medical, retail and office usersCampus visibility from Old Pecos TrailAmple parking for staff and visitorsBuilding Signage availableC-1 Zoning

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Downtown Office / Retail Space listing image
Lease OfficeRetail

Downtown Office / Retail Space

428 Sandoval St, Santa Fe, NM 87501

  • $26 SF/year
  • 1,816 SF
  • 1,816 SF building

10-Minute Walk from NM State Capitol & Other Government Buildings.Absolute Investment Realty is pleased to present this exceptional opportunity to lease a versatile office/retail commercial space located at 428 Sandoval Street in the heart ofDowntown Santa Fe, New Mexico​​The +/-1,816-square-foot space features a flexible layout suitable for a variety of professional office, retail, showroom, studio, and service-oriented uses. The property includes four private offices, a spacious open area ideal for a showroom, collaborative workspace, or customer-facing operations. ​One of the property's most attractive features is its proximity to Santa Fe's major government institutions. Located approximately half a mile from the New MexicoState Capitol and within convenient reach of the Santa Fe County AdministrativeComplex, Santa Fe City Hall, and numerous state government offices, the property provides excellent accessibility for legal professionals, consultants, government contractors, and businesses serving public-sector clients. With its central downtown location, proximity to major government offices, and adaptable floor plan, 428Sandoval Street presents an outstanding opportunity to establish a professional presence in Santa Fe's thriving commercial district.​ 10 Minute Walk to NM State Capitol​Less than 0.5 mi to the Santa Fe Plaza​Rare On-Site Parking​Large Open Showroom / Retail Layout​Flexible Office / Workspace​4 Private Offices​Full Kitchen Available​Ideal for Attorneys, Lobbyists, Multiple Different Office & Retail Users.​

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UPSCALE SANTA FE OFFICES IN PRIME LOCATION listing image
Lease OfficeHealthcare

UPSCALE SANTA FE OFFICES IN PRIME LOCATION

549 S Guadalupe St, Santa Fe, NM 87501

  • $20 SF/year
  • 100 – 3,419 SF
  • 3,553 SF building
  • 1 ac
  • 8 Spaces

Very underserved market in Santa Fe, 549 S. Guadalupe St. offers upscale office space at $20/SF, located at the high-traffic intersection of S. Guadalupe St., Paseo de Peralta, and Cerrillos Rd.—directly across from the Santa Fe Rail Yard and NM Rail Runner Station and near the Roundhouse and New Mexico government buildings.The building offers common-area conference rooms, kitchen areas, restrooms on each floor and private offices plus open work areas. The demisable ±3,419 SF Garden Level includes six executive suites (100 – 350SF), an open work/meeting area, storage and a break room – ideal for co-working, an art gallery, a yoga studio or executive offices. Suite 203 (±134SF) is fully furnished.Building Features:Building conference roomBreak room/kitchen areasRestrooms on each floorSecure key fob accessElevator and stair accessLED lightingWi-Fi throughoutProperty professionally managedLocation:Directly across from the Santa Fe Rail Yard and NM RailRunner StationIn proximity to New Mexico government buildings andestablishmentsHistoric rail turnaround in front parking lotGarden Level (±3,419 SF – Demisable):$20.00 PSF Full ServiceSix executive suites available (100 – 350 SF)Versatile open floor plan – open work/meeting areaIdeal for gathering, co-working, art gallery, yoga studio orexecutive officeStorageCommon restrooms and break room/kitchenSuite 203 (±134 SF – Second Level):$750/moFully furnished PROPERTY HIGHLIGHTS:±3,553 SF available – Garden Level ±3,419 SF(demisable) plus Suite 203 ±134 SF$20.00 PSF Full Service on the Garden LevelSix executive suites available on the Garden Level(100 – 350 SF)Directly across from the Santa Fe Rail Yard andNM Rail Runner StationClose proximity to the Roundhouse, New Mexico’sState Capitol BuildingWalking distance to world-class accommodations,dining, galleries and shoppingBuilding conference room, break room/kitchenareas and Wi-Fi throughoutSecure key fob access, elevator and stair access –professionally managed

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